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ClariTestTM Non-Invasive Prenatal Screen

While most babies are born healthy, there is always a small risk for genetic conditions to occur, regardless of age or family history. ClariTest, a non-invasive prenatal screen (NIPS), can be an important step in your prenatal care and can provide you with valuable information and peace of mind as you plan for your future.

ClariTest™ is a simple blood test performed during pregnancy that screens for the most common chromosome abnormalities caused by extra or missing genetic information in the baby’s DNA including Down syndrome, Trisomy 18, Trisomy 13, monosomy X, and certain microdeletions.

View Conditions Screened for with ClariTest

What Are Chromosomal Abnormalities?

Chromosomes are structures found in our cells that carry our genetic information. Normally, we have 46 chromosomes in our cells, which come in pairs. We inherit 23 chromosomes from each parent. The chromosome pairs are numbered from 1 to 22. The 23rd pair is the sex chromosomes. Females generally have two X chromosomes and males generally have one X and one Y chromosome. Health and development problems can occur from chromosomal abnormalities such as extra or missing chromosomes or pieces of chromosomes. The chance of having a baby with many chromosome abnormalities increases with the age of the mother.

What Are Microdeletions?

The term “microdeletion” refers to a small missing piece of a chromosome. Some microdeletions are known to cause specific genetic syndromes with major health impacts to the baby, including intellectual disabilities, heart and other birth defects, immune system problems, trouble feeding, and other complications that may need immediate care upon birth. The chance of having a baby with a microdeletion syndrome does not increase with the age of the mother.

Is ClariTest™ Right for Me?

This screening test is usually offered to pregnant women identified by their doctor to have an increased chance of a fetal chromosome abnormality. It may be an option for you to consider if you have a confirmed singleton or twin pregnancy of at least 10 weeks gestational age and meet any of the following criteria:

  • You are considered to be of advanced maternal age at time of delivery (35 years or older for a singleton pregnancy or 32 years or older for a twin pregnancy)
  • You have an abnormal or “positive” maternal serum screen
  • Your ultrasound shows concerns or abnormalities with fetal growth and/or development
  • You have a personal or family history suggestive of Trisomies 21, 18, 13, or other sex-linked chromosome abnormalities

The Reliability You Seek

Today there are a number of genetic testing options available for expectant women and their healthcare providers. ClariTest may provide a clearer picture of chromosomal health—detecting even small abnormalities with a high degree of confidence. The false positive rate is low compared to NIPS offered at other laboratories and  the test failure rate is the lowest in the industry. ClariTest can have “false negative” or “false positive” results. Diagnostic tests, such as CVS and amniocentesis, provide definitive diagnostic information and are recommended to confirm any abnormal NIPS result.

References

  1. Centers for Disease Control and Prevention. Facts About Down Syndrome. https://www.cdc.gov/ncbddd/birthdefects/downsyndrome.html. Accessed May 23, 2019.
  2. Centers for Disease Control and Prevention. Data and Statistics on Down Syndrome. https://www.cdc.gov/ncbddd/birthdefects/downsyndrome/data.html. Accessed May 23, 2019.
  3. Trisomy 18 Foundation. What is Trisomy 18. https://www.trisomy18.org/what-is-trisomy-18/. Accessed May 23, 2019.
  4. University of Rochester Medical Center. Open Neural Tube Defects (ONTDs) In Children. https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=160&contentid=90. Accessed May 23, 2019.
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